Profile
Maria Whatton
-
About Me:
I live in Basingstoke with my husband and two awesome kids, aged 12 and 14. I work as a research scientist specializing in computational medicinal chemistry for a company in Oxford. I splitting my time between the office environment and working from home.
-
Read more
As a kid, I didn’t really have a specific career dream in science. After secondary school, I thought about becoming a primary school teacher. I did well in my favorite subjects – biology, chemistry, and maths – so I continued to sixth form. Surprisingly, I excelled in A-levels, and with some encouragement from my chemistry teacher, I became the first in my family to go to university.
Beyond science, I enjoy various crafts, especially knitting, and have a soft spot for board games and jigsaws.
-
My pronouns are:
She/Her
-
My Work:
As a computational chemist specializing in medicinal chemistry, I design new chemical molecules with the goal that they might become the next big thing in medicine one day. It’s like being a builder, but instead of bricks, I work with atoms and molecules to create something that could make a difference in people’s lives.
-
Read more
Medicinal Chemistry is the science that deals with the discovery or design of new therapeutic chemicals and their development into useful medicines. My work is focused on small organic molecules it involves design of new chemical compounds (using computational techniques) which will make them suitable for therapeutic use (medicines). Key to this is understanding the structure–activity relationship (SAR) which is the relationship between the chemical structure of a molecule and its biological activity.
It’s a bit like a super-long adventure where teams of researchers spend years creating thousands of compounds on different projects. But guess what? It might take decades before they discover just one that could become a new medicine for everyone!
-
My Typical Day:
I’m like a data explorer, searching for new information from various sources. With my computer skills, I pull all the pieces together. Using what I know about chemical structures and how they connect with proteins, I play molecular architect, building models to figure out the best molecules.
It’s like putting together a puzzle to help our lab team decide what to create next.
-
Read more
I start my day by working on my projects and checking for any new data. I analyze what’s new and build computational models to predict which compounds will be best for synthetic chemists to make next. Throughout the day, I have several meetings to discuss results and plans, and I prepare for these by creating presentations of my work.
I also spend time looking at the structures of proteins, including enzymes, to design drug compounds that might connect with them and change how the proteins work. I often work with large data sets to find trends. What I love about my job is that no two days are the same, and I almost always learn something new, making each day exciting and never boring!
-
What I'd do with the prize money:
I am keen to encourage more girls to take an interest in STEM subjects. I would love to be able to donate books containing inspirational stories about women in science to local school libraries.
-
Education:
Bishop Challoner RC Secondary school in Basingstoke
Queen Mary’s Sixth Forth College, Basingstoke
Cardiff University
-
Qualifications:
9 GCSE’s (all grade A, including Maths and double award science)
A-Levels in Biology (A), Chemistry (A) in Maths (A)
Degree in Chemistry from Cardiff University (First Class Honours)
PhD in Synthetic Organic Chemistry from Cardiff University.
-
Work History:
During my A-level’s and university years I worked weekends and holidays as a general assistant in a convenience store. During my degree I did some tutoring.
After my PhD I went to work for a large global pharmaceutical company as a synthetic Medicinal chemist. The majority of my time was spent in the lab making new chemical compounds for biological testing. As I began to understand structure–activity relationships (SAR – which is the relationship between the chemical structure of a molecule and its biological activity.) I started to spend more of my time analysing the data and designing what should be made next. I worked at the same company for 19.5 years, and in later years learnt new computational techniques to aid design of new molecules.
-
Current Job:
For the past 3 years I have been working for a smaller biotech company. I hung up my lab coat and have transitioned to desk based role in computational medicinal chemistry. This involves analysing new data and building computational models to predict which compounds will be best for the synthetic chemists to make next.
-
My Interview
-
How would you describe yourself in 3 words?
Computational Medicinal Chemist
What did you want to be after you left school?
A primary school teacher.
Were you ever in trouble at school?
Never!
If you weren't doing this job, what would you choose instead?
A pharmacist
Who is your favourite singer or band?
Too hard to pick just one!
What's your favourite food?
Homemade Lasagna and chips
If you had 3 wishes for yourself what would they be? - be honest!
Good health, happiness and to own a time turner necklace so I could do more in a day!
Tell us a joke.
I tried writing jokes about the periodic table . . . . but I realised I wasn't quite in my element.
-